IMR Press / FBS / Volume 4 / Issue 4 / DOI: 10.2741/S337

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Autophagy: mechanism and physiological relevance 'brewed' from yeast studies
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1 Department of Biochemistry and Molecular Biology, Monash University, Clayton campus, Victoria 3800, Australia
2 Life Sciences Institute and Departments of Molecular, Cellular and Developmental Biology and Biological Chemistry, University of Michigan, Ann Arbor, MI 48109-2216, USA

*Author to whom correspondence should be addressed.

Academic Editor: Alan L. Munn

Front. Biosci. (Schol Ed) 2012, 4(4), 1354–1363;
Published: 1 June 2012
(This article belongs to the Special Issue The yeast model: its contribution to understanding human disease)

Autophagy is a highly conserved process of quality control occurring inside cells by which cytoplasmic material can be degraded and the products recycled for use as new building blocks or for energy production. The rapid progress and 'explosion' of knowledge concerning autophagic processes in mammals/humans that has occurred over the last 15 years was driven by fundamental studies in yeast, principally using Saccharomyces cerevisiae, leading to the identification and cloning of genes required for autophagy. This chapter reviews the role of yeast studies in understanding the molecular mechanisms of autophagic processes, focusing on aspects that are conserved in mammals/humans and how autophagy is increasingly implicated in the pathogenesis of disease and is required for development and differentiation.

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