Cite this article
29
Downloads
4
Citations
64
Views
Announcements
Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
Article
Inflammation and thrombosis: new insights
Patrick A. Lester1,2, Jose A. Diaz2, Katherine A. Shuster1,2, Peter K. Henke2, Thomas W. Wakefield2, Daniel D. Myers1,2,*
Show Less
1
Unit for Laboratory Animal Medicine, University of Michigan Medical Center, Ann Arbor, MI
2
Jobst Vascular Research Laboratories, Section of Vascular Surgery,University of Michigan Medical Center, Ann Arbor, MI
*Author to whom correspondence should be addressed.
Front. Biosci. (Schol Ed) 2012, 4(2), 620–638;
https://doi.org/10.2741/S289
Published: 1 January 2012
Abstract
Vessel wall endothelial damage initiates a local inflammatory response, which promotes a prothrombotic state driven by tissue factor, adhesion molecules, and pro-inflammatory cytokines. Understanding how natural inflammatory mechanisms promote a procoagulant state, may lead to the development of new pharmacological interventions targeted at thrombosis.