IMR Press / FBS / Volume 4 / Issue 2 / DOI: 10.2741/S289

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Inflammation and thrombosis: new insights
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1 Unit for Laboratory Animal Medicine, University of Michigan Medical Center, Ann Arbor, MI
2 Jobst Vascular Research Laboratories, Section of Vascular Surgery,University of Michigan Medical Center, Ann Arbor, MI

*Author to whom correspondence should be addressed.

Academic Editor: Arthur Chu

Front. Biosci. (Schol Ed) 2012, 4(2), 620–638;
Published: 1 January 2012
(This article belongs to the Special Issue Blood coagulation, inflammation, and thrombosis)

Vessel wall endothelial damage initiates a local inflammatory response, which promotes a prothrombotic state driven by tissue factor, adhesion molecules, and pro-inflammatory cytokines. Understanding how natural inflammatory mechanisms promote a procoagulant state, may lead to the development of new pharmacological interventions targeted at thrombosis.

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