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Article
Inflammation and thrombosis: new insights
Patrick A. Lester1,2, Jose A. Diaz2, Katherine A. Shuster1,2, Peter K. Henke2, Thomas W. Wakefield2, Daniel D. Myers1,2,*
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1
Unit for Laboratory Animal Medicine, University of Michigan Medical Center, Ann Arbor, MI
2
Jobst Vascular Research Laboratories, Section of Vascular Surgery,University of Michigan Medical Center, Ann Arbor, MI
*Author to whom correspondence should be addressed.
Academic Editor: Arthur Chu
Front. Biosci. (Schol Ed) 2012, 4(2), 620–638;
https://doi.org/10.2741/S289
Published: 1 January 2012
(This article belongs to the Special Issue Blood coagulation, inflammation, and thrombosis)
Abstract
Vessel wall endothelial damage initiates a local inflammatory response, which promotes a prothrombotic state driven by tissue factor, adhesion molecules, and pro-inflammatory cytokines. Understanding how natural inflammatory mechanisms promote a procoagulant state, may lead to the development of new pharmacological interventions targeted at thrombosis.