Immunologic mapping of glycomes: implications for cancer diagnosis and therapy

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Article

Dapeng Zhou^1,*, Steven B. Levery², Fong-Fu Hsu³, Peng G. Wang⁴, Susann Teneberg⁵, Igor C. Almeida⁶, Yunsen Li⁷, Huaxi Xu⁸, Lai-Xi Wang⁹, Chengfeng Xia¹⁰, Nuhad K Ibrahim¹¹, Katja Michael¹²

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¹ Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77054, USA

² Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark

³ Mass Spectrometry Resource, Division of Endocrinology, Diabetes, Metabolism, and Lipid Research, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA

⁴ Department of Biochemistry, The Ohio State University, Columbus, OH 43210

⁵ Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology, University of Gothenburg, P.O. Box 440, S-40530 Göteborg, Sweden

⁶ Department of Biological Sciences, University of Texas at El Paso, El Paso, TX 79968

⁷ Institute of Biological and Medical Sciences, Medical College, Soochow University, Suzhou 215123, China

⁸ School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang 212001, China

⁹ Institute of Human Virology and Department of Biochemistry & Molecular Biology, University of Maryland School of Medicine, Baltimore, MA 21201

¹⁰ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China

¹¹ Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030

¹² Department of Chemistry, University of Texas at El Paso, El Paso, TX 79968

*Author to whom correspondence should be addressed.

Front. Biosci. (Schol Ed) 2011, 3(4), 1520–1532; https://doi.org/10.2741/242

Published: 1 June 2011

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Abstract

Cancer associated glycoconjugates are important biomarkers, as exemplified by globo-H, CA125, CA15.3 and CA27.29. However, the exact chemical structures of many such biomarkers remain unknown because of technological limitations. In this article, we propose the "immunologic mapping" of cancer glycomes based on specific immune recognition of glycan structures, which can be hypothesized theoretically, produced chemically, and examined biologically by immuno-assays. Immunologic mapping of glycans not only provides a unique perspective on cancer glycomes, but also may lead to the invention of powerful reagents for diagnosis and therapy.

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