IMR Press / FBS / Volume 3 / Issue 3 / DOI: 10.2741/202

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Origins of the concept of store-operated calcium entry
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1 National Institute of Environmental Health Sciences-NIH, Department of Health and Human Services, Research Triangle Park, NC

*Author to whom correspondence should be addressed.


Front. Biosci. (Schol Ed) 2011, 3(3), 980–984;
Published: 1 June 2011

The concept of capacitative or store-operated calcium entry, a process by which the release of stored calcium signals the opening of plasma membrane calcium channels, has its roots in the late 1970's, and was formalized in 1986. This short introduction to the current volume of Frontiers in Bioscience briefly summarizes the early experimental work that led to the idea of store-operated calcium entry, and provided the initial proofs for it.

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