IMR Press / FBS / Volume 3 / Issue 2 / DOI: 10.2741/S178

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Article
Regulation of protein expression by L-arginine in endothelial cells
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1 State Key Laboratory of Animal Nutrition, China Agricultural University, Beijing, China 100193
2 Department of Obstetrics and Gynecology, China-Japan Friendship Hospital, Beijing, China 100029
3 Department of Animal Science and Faculty of Nutrition, Texas A&M University, College Station, TX, 77843
4 Cardiovascular Research Institute, Texas A and M Health Science Center, Temple, TX, 76504

*Author to whom correspondence should be addressed.

 

Front. Biosci. (Schol Ed) 2011, 3(2), 655–661; https://doi.org/10.2741/S178
Published: 1 January 2011
Abstract

L-Arginine is a conditionally essential amino acid for humans and plays an important role in the regulation of cardiovascular function and antioxidative defense. Previous studies have focused on the important role of L-arginine as a physiological precursor in the generation of nitric oxide and polyamines in endothelial cells (cells that line the interior surface of blood vessels). Because of the rapid development of high-throughput proteomics technology, there is now growing interest in studying roles for L-arginine in modulating endothelial-cell protein expression. Of particular interest, recent proteomics analysis has shown that treatment of coronary venular endothelial cells with a physiological level of L-arginine (e.g., 0.1 mM) increases expression of structural proteins (vimentin and tropomyosin) and cytochrome bc1 complex iii-chain A, while decreasing expression of stress-related proteins (PDZ domain containing-3), in these cells. These findings aid in elucidating the mechanisms responsible for the beneficial effect of physiological levels of L-arginine on the circulatory system.

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