IMR Press / FBS / Volume 2 / Issue 3 / DOI: 10.2741/S125

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Important roles of Akt/PKB signaling in the aging process
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1 Cell Differentiation and Development Center, Marshall University, Huntington, WV 25755 25755-1090, USA
2 Department of Biological Sciences, Marshall University, Huntington WV, 25755
3 Department of Exercise Science, Sport and Recreation, Marshall University, Huntington WV, 25755
4 Department of Chemistry, Marshall University, Huntington WV, 25755
5 Department of Pharmacology, Physiology and Toxicology, Marshall University, Huntington WV, 25755

*Author to whom correspondence should be addressed.

Academic Editor: Jongsun Park

Front. Biosci. (Schol Ed) 2010, 2(3), 1169–1188;
Published: 1 June 2010
(This article belongs to the Special Issue Signaling in cancer and disease)

The increased costs associated with an ever-growing aged population are expected to pose a significant burden on health care resources. From a biological standpoint, aging is an accelerated deteriorative process in tissue structure and function that is associated with higher morbidity and mortality. The Akt / protein kinase B (PKB) is a family of serine / threonine protein kinases, which play prominent roles in a diverse number of processes including cell survival, cell growth, gene expression, apoptosis, protein synthesis, energy metabolism and oncogenesis. It is likely that age-related changes in tissue structure and function are related to alterations in Akt expression and Akt-dependent signaling. Here we review the role that Akt may play in the aging process and attempt, where possible, to highlight how these data may lead to new directions of inquiry and clinical relevance to the aged.

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