IMR Press / FBS / Volume 2 / Issue 2 / DOI: 10.2741/S78

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Characterization of a three-drug nonlinear mixture response model
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1 Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
2 School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, NY 14260

Academic Editor: William R. Greco

Front. Biosci. (Schol Ed) 2010, 2(2), 454–467; https://doi.org/10.2741/S78
Published: 1 January 2010
Abstract

Our group recently developed a response-surface modeling paradigm (White et al: Curr Drug Metab 2, 399-409, 2003) and tested its application to both mixtures of anticancer agents and antifungals. This new model is a Hill-type equation, with the slope and potency parameters being functions of the normalized drug ratios, using polynomial expressions. Response surface methods allow one to model and interpret all of the information present in the full concentration-effect data set, to visualize local regions of synergy, additivity and antagonism, and even to quantify the degree of synergy or antagonism, both globally, and across local regions of the response surface. In the present article, we study the effect of changes in the different parameters of the polynomial expressions for two-drug and three-drug mixtures, on the geometrical shapes of several 2-dimensional representations of the 3-dimensional concentration-effect surface. A secondary goal of this report is to compare the mathematical characteristics of the rival White and (Minto et al: Anesthesiol 92, 1603-1616, 2000) modeling paradigms.

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