IMR Press / FBS / Volume 2 / Issue 1 / DOI: 10.2741/S49

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

The placebo response in pain and depression: in search of a common pathway
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1 Eli Lilly and Company, Indianapolis, IN 46285, USA

*Author to whom correspondence should be addressed.

Academic Editor: Joachim F. Wernicke

Front. Biosci. (Schol Ed) 2010, 2(1), 106–111;
Published: 1 January 2010
(This article belongs to the Special Issue The mood pain interface)

The placebo effect has been extensively studied in many disease states, some of the most notable being pain and depression. Utilizing a Medline search, studies were identified that reported on areas of the brain shown to be involved in either placebo analgesia or mood response. This paper presents a distillation of this research, in an effort to identify a common "placebo pathway" between mood and pain. Placebo-related responses to both analgesia and relief from depression were reported to be associated with an increase in activity in the frontal cortex and a decrease in activity in the thalamus.

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