IMR Press / FBS / Volume 2 / Issue 1 / DOI: 10.2741/S43

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

The role of nitric oxide and reactive nitrogen species in experimental ARDS
Show Less
1 Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555-0833, USA

*Author to whom correspondence should be addressed.

Academic Editor: Pal Pacher

Front. Biosci. (Schol Ed) 2010, 2(1), 18–29;
Published: 1 January 2010
(This article belongs to the Special Issue Nitric oxide, superoxide and peroxynitrite in cardiovascular diseases)

The acute respiratory distress syndrome (ARDS) is associated with a mortality ranging between 40 - 80%. An effective drug therapy, however, is still missing. Many experimental models of ARDS exist enabling a better understanding of the underlying pathophysiology and allowing the establishment of novel therapeutic strategies for the treatment of patients suffering ARDS. Nitric oxide (NO) and reactive nitrogen species (RNS) are increasingly regarded as key substances within the development of ARDS. However, the definite pathomechanism is not completely understood. The purpose of this article is to review the latest results of experimental studies in reference to the role of NO and RNS in the pathogenesis of ARDS. In addition, current large animal models of ARDS are described and future therapeutic approaches are discussed.

Back to top