IMR Press / FBS / Volume 1 / Issue 1 / DOI: 10.2741/S15

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Epigenetics and leukemia: unraveling oncogenic processes in the BLV ovine model
Show Less
1 Laboratory of Experimental Hematology, Institut Jules Bordet, Universite Libre de Bruxelles (ULB), 121 Boulevard de Waterloo, 1000 Brussels, Belgium
2 Vaccine and Infectious Disease Organization (VIDO), University of Saskatchewan, 120 Veterinary Road, Saskatoon S7N 5E3, Canada

*Author to whom correspondence should be addressed.

Academic Editor: Franco Buonaguro

Front. Biosci. (Schol Ed) 2009, 1(1), 154–163;
Published: 1 June 2009

Bovine Leukemia Virus (BLV)-induced B-cell leukemia in sheep is a valuable large animal model for investigating oncogenic mechanisms, particularly those associated with human T-cell leukemia virus 1 (HTLV-1). Multiple factors including viral genes, genetic and epigenetic alterations, and the host immune system are likely to contribute and cooperate in the leukemogenesis of adult T-cell leukemia (ATL) in human and B-cell leukemia in sheep. While considerable effort has been made to explore the role of viral determinants in the transformation process, the participation of host-related mechanisms has been poorly addressed. We discuss recent evidence from sheep studies in the context of the growing knowledge that has accumulated in the field of epigenetics in human cancer. These results support the hypothesis that epigenetic events, which were initially identified as a causative mechanism of virus silencing, are also major players in host gene regulation. Future studies in sheep will increase the number of genes identified that are aberrantly regulated by epigenetic processes and identify potential biomarkers which may be used as therapeutic targets in leukemia.

Back to top