Ion channels are membrane-spanning proteins, often associated with auxiliary subunits, mediating the selective permeation of ion species and allowing the movement of charges, depending on the electrochemical gradient. Importantly, they participate in determining plasma membrane potential and as such are critical for the activity of excitable cells in excitation-contraction, excitation-secretion or excitation-expression couplings. Their roles in non-excitable cells are also recognized in regulating the homeostasis of ions, and by this way, the transport of metabolites, the control of cell volume and related functions such as cell proliferation or apoptosis.
Mutations in ion channel genes or alterations of their expression/function can alter ion flow, disrupt the electrochemical balance and water flow regulation. Therefore, abnormalities or dysregulations in ion channels, or their regulatory subunits, have been associated with various disorders, including epilepsy, ataxia, diabetes mellitus, cardiac arrhythmia, cystic fibrosis, cancer. Ion channels are thus important therapeutic targets and attractive structures in drug discovery.
Dr. Sébastien Roger and Dr. Lin-Hua Jiang
Manuscripts should be submitted via our online editorial system at https://imr.propub.com by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2500 USD. Submitted manuscripts should be well formatted in good English.