IMR Press / FBL / Special Issues / inflammatory_diseases

Discovery of Novel Small Molecule Inhibitors of Receptor Tyrosine Kinases

Submission deadline: 30 September 2022
Special Issue Editor
  • Martin Berghoff, MD
    Justus-Liebig University of Giessen, Giessen, Germany
    Interests: receptor tyrosine kinases; small molecule inhibitors; FGF/FGFR pathways; oligodendrocytes; remyelination
Special Issue Information

Dear Colleagues,

Protein kinases regulate many aspects of normal cellular activity. Mutations or changes in the expression of protein kinase genes can therefore cause cancer as well as other diseases. Following the approval of imatinib in 2001, considerable progress has been made in the development of potent and specific small-molecule tyrosine kinase inhibitors (TKIs). To overcome resistance, inhibitors may be applied in combination with other kinase inhibitors, or with other therapeutics. To date, more than 70 TKIs have been approved for various diseases, mainly against tumours. The search for novel compounds in cancer treatment is likely to dominate future research in this field. Kinase inhibitors are also being trialled for the treatment of inflammatory and neurodegenerative diseases. In recent years, inhibitors of Bruton tyrosine kinase (BTKi) are undergoing clinical trials in patients with different forms of multiple sclerosis. These small compounds are able to cross the blood-brain barrier and may act directly on the key cells involved in multiple sclerosis pathology, such as microglia. In summary, the discovery of novel TKIs will remain an important research field over the next few decades.

Prof. Dr. Martin Berghoff
Guest Editor

Tyrosine kinase inhibitors (TKI)
inflammatory diseases
Manuscript Submission Information

Manuscripts should be submitted via our online editorial system at by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2500 USD. Submitted manuscripts should be well formatted in good English.

Back to top