Single Nucleotide Polymorphisms

Submission deadline: 30 December 2022
Special Issue Editor
Special Issue Information

Dear Colleagues,

For over 40 years it has been established that genetic variants can influence disease susceptibility, disease progression, and an individual’s response to therapy. Moreover, genetic variants have a number of benefits over other markers due to the standardized assays used and to the large-scale association studies performed to identify and validate these biomarkers. In the past decade, many studies have found that both the toxicity and efficacy of drugs can be influenced by the presence of single nucleotide polymorphisms (SNPs) in genes involved in the metabolism, transport, and function of medications. This field is known as pharmacogenetics. Although SNPs may not by themselves cause a disorder, some are responsible for genetic effects that can result in susceptibility to disease. These associations mean that SNPs can be investigated to determine an individual's genetic predisposition to developing a specific disease. Once more functional polymorphisms have been identified it may be possible to use these genetic markers in personalized medicine. The articles in this special issue will cover important aspects of SNP technology that can be used to identify disease-causing genes in humans and to understand inter-individual variation in drug response.

Dr.  Agnieszka Paradowska-Gorycka

Guest Editor

Keywords
SNP
pathogenesis
therapy
personalized medicine
genetic variants
technologies
Manuscript Submission Information

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