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Cancer Related Lymphedema - Pathology and Therapeutic Approaches

Submission deadline: 15 October 2022
Special Issue Editor
  • Raghu P. Kataru
    Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Interests: Lymphangiogensis; Inflammatory regulation; Immune responses; Fibrosis; Secondary lymphedema; T cells; Lymphatic trafficking
Special Issue Information

Dear Colleagues,

Over the past decade, the incidence of cancer treatment-related diseases such as secondary lymphedema has risen due to improved cancer survival rates. Secondary lymphedema is a life-long, debilitating disease that affects patients treated for various types of cancers including breast cancer, urologic cancer and sarcomas. Almost one-third of patients who undergo lymph node dissection surgery during breast cancer treatment develop secondary lymphedema. In the USA alone more than 6 million people are affected by cancer-related lymphedema, resulting in a significant medical burden. Although conservative options such as compression devices and massage therapies have shown some clinical benefit, lymphedema continues to have a profound impact on the quality of life in this patient population.

Despite the millions of patients who suffer from lymphedema, the pathophysiology of this disease is still not completely understood. Initially, lymphedema was considered to be a disease of lymphatic insufficiency. However, research over the past decade has led to notable advances in our understanding of the pathology of lymphedema. Recent evidence has shown that it is initiated by lymphatic damage and insufficiency propagated by chronic inflammation. This results in a connective tissue disorder involving chronic tissue fibrosis and adipose deposition. Current research is aimed at treating the disease from several directions, including the targeting of pro-lymphangiogenic, anti-inflammatory and anti-fibrotic pathways.

Additionally, advanced surgical therapies such as lympho-venous bypass and lymph node transplantation have proven to be somewhat effective in alleviating the pathology of lymphedema. This two-pronged approach involving basic research and clinical therapies is likely to be the best way forward in developing effective therapies to treat this condition. Since lymphedema only arises in some patients who undergo cancer therapies, emphasis should also be given to identifying susceptible individuals who are more prone to develop lymphedema through the use of accurate biomarkers.

The intent of this special issue is to shed light on new findings relating to lymphedema pathology, clinical therapies and prognostic approaches. In addition, this issue will summarize our current understanding of lymphedema pathology and the existing therapies used to treat this disease.

Dr. Raghu P. Kataru

Guest Editor

Cancer related lymphedema
Pathophysiology of lymphedema
Lymphatic dysfunction in lymphedema
Lymphatic pumping
Inflammation and lymphedema
Chronic obesity and lymphedema
Lymphatic muscle cells in lymphedema
Lymph node transplantation as lymphedema treatment
Weight loss and aerobic exercise in lymphedema
Lymphovenous bypass as lymphedema treatment
T cell subsets in lymphedema
Lymphedema and innate immunity
Lymphedema biomarkers
Manuscript Submission Information

Manuscripts should be submitted via our online editorial system at by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2500 USD. Submitted manuscripts should be well formatted in good English.

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