IMR Press / FBL / Special Issues / 1463798575246233601

Towards Personalized Treatment in Colorectal Cancer

Submission deadline: 30 September 2022
Special Issue Editor
Alessandro Passardi
Department of Medical Oncology, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) “Dino Amadori”, via P. Maroncelli 40, Meldola, Italy
Interests: Translational research; Angiogenesis; Colorectal cancer; Pancreatic cancer; Gastrointestinal tumors
Special Issue Information

Dear Colleagues,

Colorectal cancer (CRC) is the third most commonly diagnosed cancer in males and the second in females. Translational research has led to significant benefits in the management of patients with metastatic disease, and precision medicine is becoming the goal of scientific research.

Recent years have seen remarkable advances in the treatment of all gastrointestinal cancers. Translational research has led to significant benefits in screening and patient management, and precision medicine is fast becoming the aim of scientific research.

Individualized treatment for colorectal cancer in both adjuvant and metastatic settings is increasingly emphasized. In particular, the introduction of molecular-targeted agents has significantly improved patient outcome, but predictive markers of efficacy, especially for angiogenesis inhibition, are still lacking. Furthermore, immunotherapy has recently been implemented into clinical practice. Due to these new therapeutic options, physicians are confronted with new challenges, such as monitoring progression and stratifying patients for appropriate treatments.

The role of genetic alterations in cancer is well established. It is generally accepted, however, that genetic changes alone do not fully account for malignancy. Growing evidence has indeed implicated the involvement of epigenetic alterations in cancer. Unlike irreversible genetic mutations, epigenetic alterations are potentially reversible, which makes epigenetic therapy (modulation of epigenetic states) an appealing strategy for cancer treatment. Alterations of epigenetic marks could also serve as biomarkers for diagnosis, prognosis, and responses to therapies.

A new approach to biomarker detection is the use of liquid biopsy. Free circulating tumor DNA (fctDNA) can be monitored quantitatively and qualitatively for diagnostic, prognostic, or predictive purposes. Liquid biopsy has the potential to replace tumor tissue analysis in clinical practice and could be used to monitor the extent of tumor burden and to detect tumor heterogeneity and molecular resistance to therapy.

Dr Passardi Alessandro

Guest Editor

Predictive biomarkers of response and toxicity in the adjuvant and metastatic settings
Genetic and epigenetic markers
Prognostic biomarkers
Angiogenesis and EGFR pathways
Tumor biopsies
Circulating tumor cells
Tumor heterogeneity
Early diagnosis
Liquid biopsy
Molecular pathology
Tumor biology
Manuscript Submission Information

Manuscripts should be submitted via our online editorial system at by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2500 USD. Submitted manuscripts should be well formatted in good English.

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