New Insights against Cancer Progression and Metastasis

Dear Colleagues,

Cancer metastasis is the main cause of treatment failure and mortality in cancer patients. Cancer is a complex and heterogeneous disease process involving multiple currently undiscovered mechanisms. Understanding the molecular mechanisms, particularly those involving cancer evolution, heterogeneity and metastasis, is essential to develop safe and effective treatments, as well as implementing adequate prevention measures. There are many aspects involved in cancer progression and metastasis such as epithelial mesenchimal transition (EMT), hypoxia, tyrosine kinase activaction, angiogenesis, anoikis, drug resistance, cell adhesion and invasion, apoptosis, autophagy, and cancer stem cells. Primary tumors, especially in the early stages, can be eradicated with surgery or radiotherapy, while metastases remain the leading cause of cancer death.

The differences in cellular function between primary and metastatic tumors are key determinants for the identification of the mechanisms for metastases. A targeted approach for the treatment of cancer and metastasis is mandatory to develop a rational prevention strategy.

In this Special Issue we are seeking original research articles or literature reviews to highlight the recent efforts in understanding the molecular events that give rise to cancer progression and metastasis; and the novel therapeutic strategies to fight it. We also seek contributions that highlight the combination of natural compounds, drug repurposing or dietary approaches as strategies to inhibit cancer progression and metastases. Articles describing natural compounds or synergism between two or more drugs that have beneficial effects which could be used for the treatment of cancer and metastases are also welcomed.

Dr. Antonio Barbieri and Dr. Francesca Bruzzese

Guest Editors

Manuscripts should be submitted via our online editorial system at https://imr.propub.com by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2500 USD. Submitted manuscripts should be well formatted in good English.