- Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Goethe University, Frankfurt, GermanyInterests: Alcoholic liver disease; Alcoholic liver injury; Alcohol metabolism; Microsomal ethanol-oxidizing system; Drug induced liver injury; Herb induced liver injury; Herbal Traditional Chinese Medicine (TCM); Herbal products; Causality assessment; Roussel Uclaf Causality Assessment Method (RUCAM)
Humans may be exposed to a variety of chemicals that are potentially toxic to the liver, either in their original form or following metabolic activation to toxic intermediates by liver enzymes. These enzymes are mostly confined to the endoplasmic reticulum, corresponding to the microsomal fraction. The uptake of these toxins commonly occurs via the gastrointestinal tract after oral ingestion, but sometimes also via the lungs after inhalation of industrial chemicals such as carbon tetrachloride. Well-established chemical toxins and toxic products include ethanol, chemicals contained in conventional drugs, phytochemicals from herbal medicines including traditional Chinese medicine (TCM) and Ayurvedic medicine, and plants including fungi. Still under discussion are hepatotoxins from herbicides, pesticides, fertilizers, halogenated hydrocarbons, industrial and household solvents, heavy metals, and specifically aflatoxins and unsaturated pyrrolizidine alkaloids. Typical dose-dependent chemicals are ethanol, halogenated hydrocarbons and acetaminophen, whereas most conventional drugs and herbal medicinal products carry an unpredictable, low independent risk of liver injury. The aim of this Special Issue is to shed more light on the pathomechanistic aspects of liver injury at the molecular level caused by several potential toxins. Authors working in this area are encouraged to submit their research to this Special Issue.
Prof. Rolf Teschke
Manuscripts should be submitted via our online editorial system at https://imr.propub.com by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2500 USD. Submitted manuscripts should be well formatted in good English.
- Heavy Metals, Halogenated Hydrocarbons, Phthalates, Glyphosate, Cordycepin, Alcohol, Drugs, and Herbs, Assessed for Liver Injury and Mechanistic StepsRolf Teschke, Tran Dang XuanFront. Biosci. (Landmark Ed) 2022, 27(11), 314; https://doi.org/10.31083/j.fbl2711314(This article belongs to the Special Issue Hepatotoxicity: Molecular Mechanisms and Pathophysiology)80Downloads209Views