Signal Transduction and Gene Expression for Modeling Human Diseases

Dear Colleagues,

We will include papers and reviews that

1. follow this concept:

The use of signal transduction pathways and gene expression data as a basis for modeling diseases and as platforms to screen leads for drugs.

2. be in line with the following background:

Many diseases still require unique basic knowledge in order to develop personalized drugs with less side effects. In this issue, we plan to publish manuscripts that will address these issues.

Disease-related metabolome, proteome and transcriptome are advantageous and are termed: disease-related "metabolome/proteome/transcriptome signature".

3. Include models such as:

1) Brain diseases; and the role of the blood-Brain-Barrier

2) Aging related novel data on signal-transduction and metabolic pathways

3) Cancer diseases and related proteomic data targeting novel drugs

4) Disease models (such as epilepsy, cancer) that enable combined treatment using electrical fields and drugs

5) Harnessing data on signaling pathways and transcriptome for modeling monogenic genetic diseases as platforms to advance drug discovery

6) Genome editing (Crispr) based on signal transduction and gene expression knowledge for human disease therapies

7) Understanding how the knowledge on Signal Transduction and Gene Expression can be harnessed for treating brain diseases such as Alzheimer's Disease and Brain injuries and other pathologies.

8) Signal Transduction, Gene Expression, Proteome and Metabolome: methodologies of data collection and data analysis related to human diseases

9) Additional human diseases

4. Suggest methodologies for validation of the specificity of potential drugs.

e.g. based on metabolome/proteome/transcriptome signature.

Dr. Rivka Ofir

Guest Editors

Manuscripts should be submitted via our online editorial system at https://imr.propub.com by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2500 USD. Submitted manuscripts should be well formatted in good English.