IMR Press / FBL / Special Issues / 1438318913011503105

Immunological and molecular approaches for COVID-19 and Long-COVID-19, Diagnosis and Research

Submission deadline: 31 July 2022
Special Issue Editors
  • Amedeo Amedei, PhD
    Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
    Interests: Immunity; T cells; Microbiota; Microbiota-Immunity axis; Cancer (gastrointestinal; breast); Infectious diseases; Autoimmunity (Crohn Disease; Systemic Sclerosis); Amyotrophic lateral sclerosis (ALS); Human Addiction (cocaine)
    Special Issues and Topics in IMR Press journals
  • Edda Russo
    Department of Experimental and Clinical Medicine, University of Florence, Italy
    Interests: Immune-microbiome Axis
  • Francesca Romano
    AOUC Careggi University Hospital, Florence, Italy
    Interests: Immunological Diagnostic
  • Alessandra Fanelli
    AOUC Careggi University Hospital, Florence, Italy
    Interests: Immunological Diagnostic; Ematology; Clinical Patology
Special Issue Information

Dear Colleagues,

The severe acute respiratory syndrome (SARS)–CoV-2 RNA virus causes Coronavirus Disease 2019 (COVID-19), a current worldwide epidemic. Furthermore, recent evidence shows that many patients, who have had Covid-19, experience a range of symptoms that last long after the acute infection has gone, a condition called as chronic or Long COVID. Both Sensitive COVID and Long COVID diagnostic tests are urgently needed to successfully isolate, diagnose, and treat infected subjects, as well as to stop the virus from spreading.

Failure to do so will ultimately result in an increase in cases, overcrowding, and the eventual collapse of healthcare facilities. Furthermore, understanding the pathophysiology of this new virus and especially its interaction with the human immune system requires further investigation. The findings of such studies will help to shape public health policies and methods for identifying vulnerable people, as well as diagnostic, prognostic, and therapeutic techniques for patients.

Established virologic processes, such as nucleic acid hybridization techniques and recombinase polymerase amplification, as well as immunologic approaches, such as antibodies’ tests, are used in most current diagnostic approaches. Notably, immunologic tests are quick and need little equipment, although they are ineffective in the early stages of SARS-CoV-2 infections. Enzyme-linked immunosorbent assays (ELISAs), flow cytometry, total lab automation and mass cytometry are some of the immunological techniques used in research (CyTOF).

Each of these approaches is utilized to examine the COVID-19 pathophysiology from a different perspective, and each has its own set of benefits and drawbacks. In addition, the combination of these techniques helped us learn more about COVID-19.

Finally, the comprehension of the mechanisms that drive the severity of the infection, pathology, and the immune response is essential to better characterize disease progression and get to improving quality of life and widening the spectrum of innovative therapeutic strategies

We will cover contemporary and innovative approaches in COVID-19 and prospective methods in Long COVID 19 diagnosis and research in this special issue, with an emphasis on immunological and molecular methodologies, which are becoming more acknowledged as important components of the disease process. Notably, the know-how and the novelty of these new diagnostic/prognostic approaches could be exploited also for future epidemics by new virus.

Prof. Amedeo Amedei, Dr. Edda Russo, Dr. Francesca Romano and Dr. Alessandra Fanelli
Guest Editors


Covid 19
Long Covid 19
Manuscript Submission Information

Manuscripts should be submitted via our online editorial system at by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2500 USD. Submitted manuscripts should be well formatted in good English.

Published Paper (3 Papers)
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