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Apoptosis regulation in onset, progression and therapy of oncological diseases

Submission deadline: 30 June 2022
Special Issue Editors
Viviana di Giacomo, MD
Department of Pharmacy, University "G. d'Annunzio", Chieti-Pescara, Italy
Interests: Biomaterials; Bone regeneration; Stem cells; Oxidative stress; Apoptosis; Neuroprotection; Antitumoral drugs; Cell culture; In vitro systems; Flow cytometry
Silvia Sancilio
Department of Medicine and Aging Sciences University “G. d’Annunzio” Chieti-Pescara, Italy
Interests: Biomaterials; Scaffolds; Bone Regeneration; Stem Cells; Apoptosis; Aging; Molecular Biology; Cell Signaling
Special Issue Information

Dear Colleagues,

Apoptosis is a finely regulated cellular process in tissue homeostasis and acts predominantly during embryonic development. In this delicate phase, the deletion of redundant cellular material is necessary for the correct morphogenesis of tissues and organs; but apoptosis is also an indispensable process for the maintenance of tissue homeostasis during the entire cell life.

Furthermore, apoptosis can also be triggered in pathological conditions, where the removal of cells undergoing damage to DNA and/or cellular organelles is essential for maintaining the health of organisms. Hence, the comprehension of the regulation of apoptotic pathways can help in the development of new promising therapeutic approaches.

Oncological diseases are characterized by an imbalance between cell division and cell death. Consequently, cells that should die continue to proliferate. The error that leads to this situation can occur anywhere during the apoptotic pathway.

Cancer can indeed be thought of as the product of successive genetic errors that lead to the formation of a malignant cell and the escape from cell death is one of the fundamental changes that cause this malignant transformation. Therefore, an impairment of the apoptotic process plays a fundamental role in carcinogenesis and can occur in different ways:

· imbalance between apoptotic and anti-apoptotic proteins (e.g. Bcl-2, p53, IAPs)

· reduced or non-functioning caspases (initiator caspase e.g.-2, -8, -9, -10; effector caspase e.g. -3, -6, -7)

· impaired death receptor signaling (e.g. TNFR1, Fas, TRAIL).

This Special Issue is focused on the role of apoptosis in oncological diseases and its purpose is the investigation of the physico-chemical stimuli regulating the apoptotic process and the molecular mechanisms at the basis of apoptosis imbalance in cancer onset and progression. The research of novel therapeutic targets and approaches in cancer fits within the aims of the special issue as well.

The guest-editors invite authors to submit original research and review articles related to any of these aspects.

Assoc. Prof. Viviana di Giacomo and Assoc. Prof. Silvia Sancilio

Guest Editors

Molecular Mechanism(s)
Therapeutic Approach
Manuscript Submission Information

Manuscripts should be submitted via our online editorial system at by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2500 USD. Submitted manuscripts should be well formatted in good English.

Published Paper (1 Paper)
Open Access Original Research
Tumor-Suppressor Gene Transmembrane Protein 98 Promotes Proliferation and Inhibits Apoptosis in Ovarian Cancer
San-Gang Wu, Jing-Ying Xu, Jian Lei, Min Hu, Juan Zhou
Front. Biosci. (Landmark Ed) 2022, 27(7), 210;
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