Mammalian cellular proliferation is closely related to the key molecular pathway of regulating mitotic cycle. Normal proliferation is just like embryonic development, however, over-proliferation is just like the process of tumorigenesis, which is accompanied by abundant neoplasms.
As all we know that the events of cellular proliferation is accompanied with a mass of signaling molecular movement, such as signaling protein migration and chemotaxis. Although we have got some data about regulative proteins of cellular proliferation or mitotic promotion factor (MPF) such as PKBα/Akt1 or Cdc25B, mechanisms and the whole range of molecules involved in mitotic regulation still need to be clarified, compelling evidences suggest that MPF are the key link. What are its regulative proteins? And what are the function of these proteins? The aberrant conformations of these proteins are believed to determine and change the process of cell cycle, which is of great significance to clinic diagnosis and treatment.
The definite diagnosis of neoplasm requires clinic pathological analysis and relies on detection of molecular biology on these proteins in body. In vivo diagnosis is based on the clinical presentation and pathological image, and has been recently improved by the availability of biomarkers, most of which are related to secondary changes.
In addition, the process of embryonic development is also regulated by MPF, so the aberrant conformations of regulative proteins may affect embryonic status and produce deformity.
In the last few years, thanks to the better understanding of these diseases and striking technological advancement (e.g. the development of innovative and ultrasensitive tools), significant progresses have been made toward biomarkers tightly linked to the core pathology of these diseases. In particular, the development of (1) cellular and animal models that better recapitulate the most important features of cell proliferation; (2) new disease biomarkers, and (3) new technologies and disciplines (e.g. metagenomics, structural and molecular biology, biophysics, biochemistry and artificial intelligence) exploitable for disease research, diagnosis and treatment, are revolutionizing challenge to cell proliferation.
The aim of this special issue is to present the most recent discoveries associated with different facets of cell proliferation, including pathology, basic research, and classical or innovative diagnostic approaches that might be on the frontiers of research in the field.
Prof. Xin Deng, Prof. Huazhe Yang and Assoc. prof. Shuo Liu
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