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Oxidative Damage in Neurological Dysfunction/Diseases: Causes and Prevention

Submission deadline: 31 December 2021
Special Issue Editors
Special Issue Information

Dear Colleagues,

Oxidative/nitrosative stress are major contributors to neurological damage and central nervous system diseases. Its high vulnerability stems in part from is elevated requirement for glucose and oxygen; the brain utilizes 20% of the inhaled oxygen even though it is only 2% of the body weight. Any reduction in the oxygen tension in neurons is accompanied by rapid changes in mitochondrial metabolism and ATP production, which is needed to sustain optimal neuronal physiology. These changes exaggerate reactive oxygen species production due to malfunction of the electron transport chain and the activation of cellular oxidases These destructive agents mutilate critical molecules generically-referred to as oxidative stress; this culminates in apoptosis, autophagy, mitophagy, etc. Loss of neurons is particularly serious since, with few exceptions, neurons are not replaced. Numerous attempts and agents have been tested in recent years relative to their ability to attenuate neural damage that occurs as a result of oxygen deprivation, toxin exposure, or as a result of disease processes. The molecules tested include endogenously-produced agents, e.g., melatonin, as well as vitamins and many other plant-derived, naturally-occurring agents as well as synthetic pharmaceutical drugs. The ability to modulate and/or delay diseases processes in the central nervous system is a high priority considering the increased longevity of humans. Old age is a major predisposing factor for the elevated likelihood of the development of neurological impairment. The intent of this special issue is to assemble the published information which describe the causes of neurological damage/diseases as well as data related to the preservation of neural and cognitive functions throughout life.

Prof. Russel J Reiter and Assoc. Prof. Ramaswamy Sharma

Guest Editors

Alzheimer Disease
Parkinson Disease
Huntington Disease
Multiple Sclerosis
Amyotrophic Lateral Sclerosis
Viral/Bacterial Meningitis
Special Senses
Oxidative Stress
Nitrosative Stress
Mitochondrial Dysfunction
Glymphatic System
Blood Brain Barrier
Ischemic Stroke
Hemorrhage Stroke
Neural Trauma
Oxygen Deprivation
Neural Vascular System
Reactive Oxygen Species
Free Radicals
Spinal Cord Injury
Manuscript Submission Information

Manuscripts should be submitted via our online editorial system at by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2500 USD. Submitted manuscripts should be well formatted in good English.

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