IMR Press / FBL / Special Issues / 1413302859017408513

Novel Pathogenesis and Therapeutic Strategies for Degenerative Intervertebral Disc Disease

Submission deadline: 31 December 2022
Special Issue Editors
Pei Li
Department of Orthopedics, Tissue Repairing & Biotechnology Research Center, The Third Affiliated Hospital of Chongqing Medical University
Interests: Orthopedics; Degenerative Intervertebral Disc Disease; Biomarkers Discovery; Molecular Biology; Mechanobiology
Yiyang Wang
Department of Orthopedics, Tissue Repairing & Biotechnology Research Center, The Third Affiliated Hospital of Chongqing Medical University
Interests: Intervertebral Disc Degeneration; Biotherapy; Biomaterial; Tissue Engineering; Translational Medicine
Special Issue Information

Dear Colleagues,

The degenerative disease of the intervertebral disc (IVD) and back pain are chronic conditions that are caused by several factors and represent an important cause of morbidity and mortality in everyday clinical practice. The IVD comprises three regions: the bony and cartilaginous endplates (EPs) sandwiching the central nucleus pulposus (NP) and the peripheral annulus fibrosus (AF). IVD degeneration can be described as an aberrant, cell-mediated response to progressive structural failure of the IVD, involving pathological changes in all of the aforementioned structures. Because of the poor self-repair ability of the IVD tissue, there is no satisfactory way to reverse the IVD degeneration, and current treatment approaches are mostly salvage strategies. Techniques of regenerative therapy are very promising, although most of them are currently in the experimental phase. Ideal IVD regenerative therapies aim to restore the functional disc matrix, and the prospective approaches include biotechnology, tissue engineering, and novel surgical Interventions. In this special issue, we solicit original research articles and review articles focusing on pathogenesis of IVD degeneration and how to overcome the obstacles of IVD regeneration by developing innovative therapeutic strategies, especially regarding biotechnology, tissue engineering, and surgical Interventions. We hope that this proposal will foster discussion between researchers about the factors initiating disc degenerative processes and the promising therapeutic strategies to help IVD regeneration.

Dr. Pei Li and Dr. Yiyang Wang

Guest Editors

Intervertebral Disc Degeneration
Matrix Homeostasis
Tissue Engineering
Manuscript Submission Information

Manuscripts should be submitted via our online editorial system at by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2500 USD. Submitted manuscripts should be well formatted in good English.

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