Therapeutic strategies in human RNA virus infections: intervention on inflammatory response and development of anti-viral drug
Families of RNA viruses that are infectious to human, such as the Coronaviridae, Flaviviridae, Filoviridae, and Orthomyxoviridae, collectively have great potential to cause epidemic diseases in human populations. Recently, the pandemic of COVID-19 caused by SARS-CoV-2 and its tendency to mutation has raised the attention of therapies during RNA virus infection. Although the vaccines against many kinds of RNA virus, such as Poliovirus, Enterovirus 71, Influenza A virus, SARS-CoV-2, protect most of human populations from severe infectious diseases, it is urgent and of importance to optimize therapeutic strategies concerned on the adjustment of host inflammation and the control of virus shedding.
In order to effectively deal with the challenge of RNA viruses, it is necessary to continuously utilize various drug targets of both viral structural and non-structural proteins to develop antiviral drugs. In addition, cytokine storm intrigued by virus infection constitutes a risk factor for severe disease course, so the study of the intervention on the cytokine storm or inflammatory response caused by virus invasion in human organism also has a positive effect on antiviral therapeutic strategy.
This special issue welcomes studies focusing on therapeutic strategies in human RNA virus infections, emphasizing on intervention on inflammatory response and development of anti-viral drug. We are looking forward to submission for both original research and review articles that are involved in these themes.
Assoc. Prof. Zhen Luo and Assoc. Prof. Huahao Fan
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