IMR Press / FBL / Special Issues / 1408364744460914689

MAPKs and Oncogenesis

Submission deadline: 01 January 2022
Special Issue Editor
  • Guan Chen, MD, PhD
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Watertown Plank Road Milwaukee, WI, USA
    Interests: p38MAPKs; Ras oncogene; Signal transduction; Nuclear receptors; Colon; Pancreatic and breast cancer
    Special Issues and Topics in IMR Press journals
Special Issue Information

Dear Colleagues,

Kinases can amplify oncogenic signals by phosphorylating substrates and thereby play a decisive role in oncogenesis. Deregulated kinases in cancer are druggable and represent attractive targets for therapeutic intervention, and their precise roles in oncogenesis, however, are mostly not well-established. Mitogen-activated protein kinases (MAPKs) play a fundamental role in relaying and processing extracellular and intracellular signals to regulate cell growth, cell death and cell transformation through substrates, target genes, interacting partners, and cross-talking with other pathways. For example, extracellular-signal regulated kinases (ERKs) are major proliferative pathways for Ras and other oncogenes, whereas p38 and c-Jun N-terminal kinases (JNKs) are activated by stress signaling and inflammation stimulus and can either promote or inhibit inflammation-associated cancer. Recent genetic studies show that p38 MAPK family proteins play a cell-type dependent and isoform-specific role in inflammation and in inflammation-associated cancer. This knowledge is critical for understanding basic mechanisms of oncogenesis and is fundamentally important for precision oncology. This special issue aims to update recent developments in the field of MAPKs and oncogenesis and discuss potential approaches to effectively intervene tumorigenesis by targeting a specific MAPK pathway.

Prof. Guan Chen, MD, PhD

Guest Editor

Keywords
MAPKs
Oncogene
Tumorigenesis
Inflammation-associated Cancer
Target Therapy
Manuscript Submission Information

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Published Paper (3 Papers)
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