IMR Press / FBL / Special Issues / 1396637513225261058

Cancer of unknown primary site of origin: is it time to solve the labyrinth?

Submission deadline: 20 May 2022
Special Issue Editors
Giulia M. Stella, MD
Laboratory of Biochemistry and Genetics, Pneumology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
Interests: Identification of target biomarkers of malignant pleural mesothelioma and design of new therapeutic approaches based on the application of nanotechnologies; Study of biomarkers of lung cancer, with particular reference to the role of the MET oncogene in the process of metastatic dissemination; Study of the molecular profile of metastatic tumors with occult primitiveness; More recently I have been interested in studying the common biomolecular mechanisms between cancer and pulmonary fibrosis
Special Issue Information

Dear Colleagues,

Over the past few years, the improved knowledge on the biological, genetic and molecular heterogeneity of tumors, together with the development of pharmacological technologies has allowed the identification of molecular targets for novel therapeutic strategies. This rapidly evolving process has led to the overall reconsideration of the biological and genetic peculiarities that characterize each malignant disease. The identification of patients likely to respond to specific treatments according to the presence of relevant molecular targets (personalized medicine) needs clinical studies focused on a constant and productive interaction among the professionals with a significant background in the various disciplines.

Despite relevant progresses some malignant entities are still obscure and, in some cases, for instance, their own origin cannot be easily identified. These enigmatic cases, representing about 3% of all cancer diagnosis, are defined as cancers of unknown primary (CUP)and represent a constant challenge in both clinical and translational oncology. Growing amount of data are available regarding the biologic landscape of CUP as well as novel techniques to identify the putative site of organ, and many results will be available in the next few years. Those finding will help to both clarify pathogenic mechanisms and to identify actionable therapeutic targets.

The present issue aims at summarizing state of the art data on biology and clinical management of CUPs as well at collecting novel experimental results from basic and translation research approaches.

Dr. Giulia M. Stella

Guest Editor

Cancer of Unknown Primary
Malignant Disease
Clinical and Translational Oncology
Manuscript Submission Information

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