IMR Press / FBL / Special Issues / 1390560851249213442

Advances in therapeutic applications of extracellular vesicles

Submission deadline: 31 May 2022
Special Issue Editors
Gustavo Yannarelli, PhD
Principal Investigator, National Scientific and Technical Research Council (CONICET), Argentina; Director, Gene Regulation & Stem Cells Laboratory, Institute for Translational Medicine, Transplantation and Bioengineering (IMeTTyB), Favaloro University–CONICET, Buenos Aires, Argentina
Interests: Mesenchymal Stem Cells; Extracellular Vesicles; Tissue Regeneration; OCT4; Multipotency; Differentiation
Special Issue Information

Dear Colleagues,

Cells produce and secrete diverse types of membrane vesicles essential for intercellular communication. These extracellular vesicles (EVs) are spherical structures limited by a lipid bilayer and display a particular biological activity depending on their parental cells. Their cargo includes proteins, messenger RNAs, microRNAs, and other regulatory molecules that could be transferred into recipient cells to modulate their function.

Mesenchymal stromal cell (MSC)-secreted small EVs (sEVs, diameter of 30–150 nm) are increasingly recognized as critical paracrine factors responsible for MSC biological and therapeutic function. Besides, EVs from other cell types have recently demonstrated therapeutic potential. Thus, EVs constitute an attractive alternative to traditional cell-based therapies. Compared to cell therapy, EVs may have a superior safety profile, can be produced in large quantities, and safely stored without losing function (potential cell-free, off-the-shelf therapy). However, research on EVs has met many technological challenges that need to be addressed before clinical translation: i) standardized techniques to purify, characterize and quantify EVs; ii) quality control assessment of EVs by potency assays; iii) effectiveness of EVs vs. classical cell-therapies; iv) cost-efficiency between the productions for cells vs. EVs.

Overall, this Special Issue aims to make an essential contribution to the field of EVs that is expanding mainly because of their biological importance and potential to generate new therapies. Tremendous efforts are currently being made to develop purification procedures for EVs, analyze the thousands of components they contain, and determine their therapeutic effects in different pathologies.

I am pleased to invite you to contribute original research and review articles on this exciting research area.

Prof. Dr. Gustavo Yannarelli

Guest Editor

Extracellular Vesicles
Cell-free Therapy
Tissue Regeneration
Manuscript Submission Information

Manuscripts should be submitted via our online editorial system at by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2500 USD. Submitted manuscripts should be well formatted in good English.

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