Inflammation is an integral part of many physiological functions triggered in response to pathogen infection or tissue damage, which quickly ends in the normal environment. However, in many chronic conditions, the inflammatory response continues and leads to chronic inflammation, immunosenescence as well as significant tissue and organ damage. Moreover, the effects of chronic inflammation can be observed throughout life and they may increase the risk of death. Age-related alterations of the immune system and autoimmunity represent a complex, multifactorial, and poorly understood series of events that affect both the innate and adaptive compartments. In these diseases onset as well as disease course dependent on interactions between different genetic/epigenetic/immunological and environmental or life style factors. Research results open up new strategies for early diagnosis, prevention and treatment of a wide range of diseases associated with systemic chronic inflammation. The articles in this special issue should cover the important aspects in the area of inflammation dysfunction in autoimmune diseases and age-related diseases, which would supply some novel ideas for diagnosis and treatment in these diseases, including molecular and cellular studies, correlation between genetics/epigenetics and phenotype of the disease, discovery of new subset of T and B cells, as well as personalized medicine.
Dr. Agnieszka Paradowska-Gorycka
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