IMR Press / FBL / Special Issues / 1379991938144890881

Biomarkers of oxidative stress associated diseases

Submission deadline: 28 February 2022
Special Issue Editor
  • Neven Zarkovic, PhD, MD
    Rudjer Boskovic Institute, Division of Molecular Medicine, Bijenicka 54, HR-1000 Zagreb, Croatia
    Interests: Oxidative stress; Lipid peroxidation; Cancer growth control; Immunochemistry; Pathophysiology
    Special Issues in IMR Press journals
Special Issue Information

Stress- and/or age-associated diseases are considered as major socio-economic health problem of the modern society. These include various cardiovascular diseases represented usually by atherosclerosis, degenerative disorders, notably neurodegenerative, metabolic diseases represented by diabetes mellitus, autoimmune disorders, such as rheumatoid arthritis and cancer being the most fearsome of all.

Etiopathogenesis of so various diseases is generally considered to be based on the accumulation of irreparable biomolecular damages that occur over the lifetime of an individual due to harmful effects of various stressors including reactive oxygens species, especially free radicals. Therefore, excessive production of oxygen free radicals and reactive oxygen species, denoted as oxidative stress, is considered to be either crucial factor of their pathogenesis or at least important co-factor that initiates or promotes chain reactions of vicious circle, which turns reversible pathophysiological processes into irreversible diseases.

Typical example of such undesirable oxidative stress events are inflammatory processes that do not serve to defend the organism but are instead progressive and destructively acting against targeted cells or organs leading to systemic diseases. That stands also for metabolic syndrome, which is preconditioning the onset of cardiovascular diseases and diabetes mellitus. In both cases self-catalyzed or enzymatically generated process of lipid oxidation is complementing inflammation eventually generating the end products of lipid peroxidation, reactive aldehydes, which allow chronic persistence and spread of macromolecular damage at the side of the affected tissue or even beyond, after the end of the oxidative stress that initiated the damage.

Accordingly, biomarkers of oxidative stress can be unspecific and unreliable, unless well combined with specific biomarkers of particular disease. If analyzed together, they could help better understanding specific etiopathogenesis, that could lead to better prevention and/or therapies of oxidative stress associated diseases. To do that, research on complementarity of specific biomarkers of oxidative stress associated diseases and the biomarkers of oxidative stress is needed to provide functional framework for better understanding of such diseases.

Therefore, the aim of this special issue is to present some of the already gained findings on this complex aspects of pathophysiology and/or pathology of oxidative stress together with genuine research articles that might be on the frontiers of research in the field.

Prof. Dr. Neven Zarkovic

Guest Editor

Free Radicals
Oxidative Stress
Human Diseases
Manuscript Submission Information

Manuscripts should be submitted via our online editorial system at by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2500 USD. Submitted manuscripts should be well formatted in good English.

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