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Tumor antigens: from spontaneous immune response in cancer patients to cancer vaccines

Submission deadline: 31 January 2022
Special Issue Editors
  • Roberto Bei, MD
    Department of Clinical Sciences and Translational Medicine, University of Rome, Tor Vergata, Rome, 00133 Italy,Center for Regenerative Medicine, (CIMER), University of Rome “Tor Vergata”, Rome, 00133 Italy
    Interests: Oncology: analysis of immune response to tumor associated antigens in cancer patients and cancer immunotherapy; Analysis of the expression of tumor antigens in tumors and normal tissues; Effect of natural compounds on cancer cell growth
  • Laura Masuelli
    Department of Experimental Medicine, University of Rome "Sapienza"
    Interests: Cancer Immunotherapy and Anti-cancer Drugs
Special Issue Information

Dear Colleagues,

The aim of specific active cancer immunotherapy is to stimulate the host's immune response against cancer cells through direct immune system stimulation using a platform carrying one or more tumor antigens (TAs). The outcome of the cancer vaccine should be the recognition of the cancer cell-expressed TAs by specific immune effectors. Thus, the identification of TAs is crucial for the development of effective cancer vaccines. TAs can be divided into tumor-specific antigens (TSAs), that are unique antigens expressed by tumor cells and not by normal cells, and tumor-associated antigens (TAAs), which are also expressed by normal cells although at lower levels than in tumor cells. TAs include mutated antigens, oncofetal antigens (OFs), cancer-testis antigens (CTs), aberrantly glycosylated and expressed antigens, tissue lineage antigens, overexpressed antigens and virally-encoded antigens. The purpose of this special issue is to collect research articles or review that emphasize the role of the humoral and cellular immune response against tumor antigens including neoantigens to mediate tumor rejection. In addition, studies and reviews of cancer vaccines targeting Tumor Antigens are welcome.

Prof. Roberto Bei and Assoc. Prof. Laura Masuelli

Guest Editor

Keywords
Tumor Antigens
Immune Response
Cancer Vaccine
Manuscript Submission Information

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Published Paper (3 Papers)
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