IMR Press / FBL / Volume 9 / Issue 5 / DOI: 10.2741/1432

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
The promise and challenge toward the clinical application of maspin in cancer
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1 Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA
Academic Editor:Q. Ping Dou
Front. Biosci. (Landmark Ed) 2004, 9(5), 2733–2745; https://doi.org/10.2741/1432
Published: 1 September 2004
(This article belongs to the Special Issue Potential molecular targets for chemoprevention)
Abstract

Since the identification of the human maspin gene, a decade of extensive research revealed the promise of maspin both as a valuable molecular marker for the diagnosis and prognosis of many types of cancers, and as a tumor suppressor at the level of tumor growth, invasion, angiogenesis, metastasis, and tumor sensitivity to drug-induced apoptosis. This review is intended to summarize the consensus of these findings, and provide an overview of the current challenges toward the clinical application of maspin. Specifically, this review discusses several likely molecular mechanisms underlying (1) the differential regulation of maspin expression, and (2) the biological activities of maspin in tumor progression.

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