IMR Press / FBL / Volume 9 / Issue 1 / DOI: 10.2741/1145

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Blood vessels and parkinsonism
Show Less
1 Experimental Neurology and Neurosurgery, Department of Human Anatomy and Psychobiology, School of Medicine, Campus Espinardo,University of Murcia, Murcia, Spain
2 Department of Neurological Sciences and Research Center for Brain Repair, Rush University, Chicago, IL, USA
3 INSERM U289 Hôpital de la Salpêtrière, Paris, France
Academic Editor:Marina Emborg
Front. Biosci. (Landmark Ed) 2004, 9(1), 277–282; https://doi.org/10.2741/1145
Published: 1 January 2004
(This article belongs to the Special Issue Parkinson disease)
Abstract

Blood vessels are the way for nutrients present outside the brain to gain access into the cerebral parenchyma. When neurons are diseased, for example by toxin exposure, reactive glial cells secrete local factors that induce microangiogenesis, probably as part of a spontaneous neuroprotective mechanism related to the increased metabolic demand. In Parkinson's disease (PD) and non human primate models of PD, nigral degeneration is associated with gliosis and microvascular proliferation. Interestingly, microangiogenesis also facilitates the entrance into the brain parenchyma of neurotoxins and harmful cytokine-releasing blood cells, both of which have been linked to neuronal cell death in PD. In the present review we discuss the potential implications of vascular-related phenomena with mechanisms of neuronal damage in PD.

Keywords
Parkinson’s disease
MPTP
Inflammation
Blood Vessels
Glia
Iron
Review
Share
Back to top