IMR Press / FBL / Volume 8 / Issue 6 / DOI: 10.2741/1192

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

The transfer of protons in water wires inside proteins
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1 Department of Physiology, Loyola University Medical School, 2160 South First Avenue, Maywood, IL, 60153, USA

Academic Editor: Michael Green

Front. Biosci. (Landmark Ed) 2003, 8(6), 1118–1139;
Published: 1 September 2003
(This article belongs to the Special Issue Proton transport in biological systems)

The translocation of protons across membrane proteins is an essential phenomenon in biology. Only in recent years however, have we started to study in detail some of the basic features of proton transfer in water molecules inside proteins at the single molecule level. Due to their truly unique features, gramicidin-based ion channels have been used to probe proton transfer in both experimental and computational fronts. In this article, some of the new experimental findings on proton transfer in water molecules inside proteins will be reviewed. The results, their interpretations, and the perspectives toward the understanding of structure-function illations of proton transfer in proteins are discussed.

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