IMR Press / FBL / Volume 8 / Issue 6 / DOI: 10.2741/1100

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Article
Early onset parkinsonism
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1 Sección Enfermedades Extrapiramidales, Centro Neurológico-Hospital Francés & Laboratory of Experimental Parkinsonism, Instituto de Investigaciones Farmacológicas, ININFA-CONICET, Buenos Aires, Argentina
Front. Biosci. (Landmark Ed) 2003, 8(6), 568–578; https://doi.org/10.2741/1100
Published: 1 May 2003
Abstract

Early-onset parkinsonism refers to those patients with onset of a parkinsonian syndrome before age 40. These cases can be further subdivided into Young-onset (between ages 40 and 21) and Juvenile-onset (below age 21). In this review we will focus on the peculiar clinical features that distinguish these cases from classic late-onset parkinsonism, their characteristic response to medication, and their heterogeneous pathogenesis, including recent findings in the field of genetics that would suggest that a significant number of these patients are the result of genetic mutations.

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