IMR Press / FBL / Volume 8 / Issue 6 / DOI: 10.2741/1013

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Chromatin dynamics and DNA repair
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1 Research Institute for Radiation Biology and Medicine, Department of experimental oncology, Hiroshima University, Hiroshima 734-8553, Japan
2 Institut Andre Lwoff, CNRS UPR 9079, Villejuif, 94801, France

Academic Editor: Maria Avantaggiati

Front. Biosci. (Landmark Ed) 2003, 8(6), 149–155; https://doi.org/10.2741/1013
Published: 1 January 2003
(This article belongs to the Special Issue DNA metabolism within a nucleosomal context)
Abstract

Packing of the eukaryotic genome into chromatin poses an accessibility problem for the DNA repair machinery. Chromatin structure has to be changed for the repair to occur, and we are beginning to discover how different chromatin modifying mechanisms facilitate DNA repair in the chromatin context. On the other hand, the repair-related changes in chromatin should be transient, and a particular chromatin state should be able to survive the repair process. Defects in the proper maintenance of chromatin states after repair could be a factor in the aging process, as well as in other pathologies.

Keywords
DNA Damage
Repair
Chromatin
Epigenetics
Review
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