Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
1 Department of Biological Sciences, 1392 Lilly Hall of Science, Purdue University, West Lafayette, IN 47907-1392, USA
Abstract
Retroviral vector-mediated gene transfer has been contributing to studies in developmental biology, genetics and clinical science. Retroviruses are ideal tools for gene transfer into dividing cells both in vitro and in vivo, which has led to their expanding use in developing systems. In this review we will primarily review their use for ectopic gene expression and lineage analysis to study cell differentiation in murine and chick embryos.