IMR Press / FBL / Volume 8 / Issue 4 / DOI: 10.2741/1034

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Article
The insulin-like growth factor/insulin system in epithelial ovarian cancer
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1 Endocrine Research Unit, Mayo Clinic and Foundation, Rochester, MN 55905, USA
Front. Biosci. (Landmark Ed) 2003, 8(4), 714–722; https://doi.org/10.2741/1034
Published: 1 May 2003
Abstract

Ovarian cancer is the most lethal of the gynecologic malignancies, in part because the lack of striking symptoms in many women often results in diagnosis only after the disease has spread. In order to develop rational biologic or pharmacologic therapies, it is important to understand the biology of both normal and malignant ovarian epithelial cells. This review will summarize current knowledge of the expression and function of proteins in the insulin-like growth factor system in ovarian epithelium, including the peptide ligands, receptors, binding proteins, and binding protein proteases. All components of this complex regulatory system are present in the ovarian epithelium and may play important roles in regulating the normal biology of ovarian surface epithelial cells or the transformed phenotype of ovarian carcinoma cells.

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