IMR Press / FBL / Volume 8 / Issue 1 / DOI: 10.2741/933

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Photocarcinogenesis: measuring the reproducibility of a biologic response to ultraviolet radiation exposure in mice
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1 The Center for Photobiology, Argus Research, Charles River Laboratories Discovery and Development Services, Horsham, PA, 19044, USA

Academic Editor: Homer Black

Front. Biosci. (Landmark Ed) 2003, 8(1), 26–33; https://doi.org/10.2741/933
Published: 1 January 2003
(This article belongs to the Special Issue Photocarcinogenesis)
Abstract

New drugs undergo safety evaluations of many types. For some drugs, a photocarcinogenesis study forms one of the elements in the overall toxicology package. Photocarcinogenesis studies are designed to evaluate a drug's ability to modify the growth and development of ultraviolet radiation (UVR)-induced skin tumors in albino hairless mice. "Exposure control" groups in such studies receive the UVR, either alone, or in combination with the "vehicle" or carrier associated with each study. This report presents skin tumor data from control groups compiled from nine consecutive studies conducted at this testing facility. The endpoints evaluated included median tumor onset, mortality-free prevalence and tumor yield. "Historical control data" are considered essential for designing, monitoring, interpreting and evaluating studies of a given type. In addition, a compilation of such control data can illustrate trends or provide measures of reproducibility more reliably than can individual studies. This data set shows how clearly the UVR-induced skin tumor onset time is dependent on UVR dose, how skin tumors develop sooner in female mice than in male mice at a low UVR exposure dose, and that topical administration of certain vehicle formulations can enhance photocarcinogenesis.

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