IMR Press / FBL / Volume 8 / Issue 1 / DOI: 10.2741/1025

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Membrane and synaptic effects of anti-S-100 are prevented by the same antibodies in low concentrations
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1 “Materia Medica Holding” Research and Production Company, Moscow
2 Institute of Molecular Biology and Biophysics, Siberian Department of Russian Academy of Medical Sciences, Novosibirsk
3 Kazan Physicotechnical Institute, Kazan, Russia
Front. Biosci. (Landmark Ed) 2003, 8(1), 79–84;
Published: 1 May 2003

Effects of antiserum to S-100 protein (AS-100) in high (HC, corresponding to antiserum dilution 1:5 – 1:50) and low (LC, 1:1012) concentrations were studied in identified snail neurons and rat hippocampal slices. HC-AS-100 changed the frequency of action potential generation in spontaneously active neurons and blocked formation of long-term potentiation in mossy fiber synapses. LC-AS-100 alone did not affect any characteristic measured in our experiments, but 20 min pre-incubation of snail ganglia or hippocampal slices with LC-AS-100 abolished the effects of the same antibodies in HC. Simultaneous addition of both LC and HC did not prevent the development of HC-AS-100 effects. It seems possible that LC-AS-100 is capable of interaction with neuronal cells modifying their reaction to HC-AS-100.

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