IMR Press / FBL / Volume 7 / Issue 5 / DOI: 10.2741/hahn

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Chlamydia pneumoniae as a respiratory pathogen
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1 Arcand Park Clinic, Dean Medical Center, Madison WI 53704
2 Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison. WI 53706
3 Department of Medical Microbiology and Immunology, University of Wisconsin - Madison, WI

Academic Editor: Jeffrey Cirillo

Front. Biosci. (Landmark Ed) 2002, 7(5), 66–76; https://doi.org/10.2741/hahn
Published: 1 March 2002
(This article belongs to the Special Issue Bacterial respiratory pathogens)
Abstract

Chlamydia pneumoniae is a recently recognized human respiratory pathogen with a unique biphasic life cycle characterized by an obligate intracellular (replicative) and an extracellular (infectious) form of the organism. C. pneumoniae is widely distributed and, via the respiratory route, infects the majority of the world's population. The majority (70%) of acute human C. pneumoniae respiratory tract infections are asymptomatic or only mildly symptomatic but a minority (30%) cause more severe respiratory illnesses including community-acquired pneumonia, bronchitis and a variety of upper airway illnesses. After acute infection the C. pneumoniae intracellular life cycle is characterized by the development of metabolically inert (and thus antibiotic resistant) atypical "persistent" inclusions; this biologic behavior correlates with a clinical course following acute symptomatic illness that is characterized by persistence of symptoms that are difficult to treat with antibiotics. A role for C. pneumoniae in chronic respiratory illness is currently under investigation: "persistent" intracellular inclusions contain increased quantities of chlamydial heat shock protein 60 (hsp 60), a highly immunogenic protein that has been implicated in the pathogenesis of established chronic inflammatory chlamydial diseases (blinding trachoma, pelvic inflammatory disease and tubal infertility). An emerging body of evidence, including host immune response to chlamydial hsp 60, links C. pneumoniae infection with a spectrum of chronic inflammatory lung diseases of currently unknown etiology (asthma, chronic bronchitis and chronic obstructive pulmonary disease (COPD)). Further laboratory developments, including reliable and practical diagnostic methods and antibiotics effective against persistent infection, will be required to recognize and treat acute C. pneumoniae infection, and to advance our knowledge and understanding of the role of chronic infection in asthma, chronic bronchitis and COPD.

Keywords
Chlamydia pneumoniae
Acute Respiratory Illnesses
Bronchitis
Pneumonia
Chronic Respiratory Illnesses
Asthma
Chronic Obstructive Pulmonary Disease
Review
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