IMR Press / FBL / Volume 7 / Issue 4 / DOI: 10.2741/pellicen

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Coupling kinase activation to substrate recognition in SRC-family tyrosine kinases
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1 Laboratories of Molecular Biophysics and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
2 Department of Physiology and Biophysics, School of Medicine State University of New York at Stony Brook, Stony Brook, NY 11794, USA
Front. Biosci. (Landmark Ed) 2002, 7(4), 256–267;
Published: 1 January 2002

Signal transduction molecules translate extracellular inputs into their corresponding intracellular responses. Given the complexity and number of signaling pathways present in the eukaryotic cell, it is not surprising that the functions of signaling molecules are often tightly regulated. Autoinhibition is a prevalent mechanism for governing the function of signaling molecules. The relationship between the viral, oncogenic form of Src (v-Src) and the corresponding cellular proto-oncogene (c-Src) highlights the importance of inhibitory intramolecular interactions. Src provides an example of the dramatic cellular consequences arising from the loss of autoregulation.

SH3 domain
SH2 domain
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