IMR Press / FBL / Volume 7 / Issue 4 / DOI: 10.2741/neuveut

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Cell cycle dysregulation by HTLV-I: role of the tax oncoprotein
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1 Laboratoire de Recombinaison et Expression Genetique, Institut Pasteur, 28, rue du Dr Roux. 75724 Paris cedex 15, France
2 Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Building 4 Room 306, 9000 Rockville Pike, Bethesda MD 20892-0460, USA
Academic Editor:Richard Zhao
Front. Biosci. (Landmark Ed) 2002, 7(4), 157–163; https://doi.org/10.2741/neuveut
Published: 1 January 2002
(This article belongs to the Special Issue Cell cycle control in viral Infection)
Abstract

HTLV-I is a human retrovirus which is the etiological agent for adult T-cell leukemia. The virus encodes a 40 kDa oncoprotein, Tax, which has no cellular counterpart. Findings from several laboratories over the past decade have shown that over-expression of the Tax oncoprotein is wholly sufficient to transform animal cells. Emerging evidence supports that Tax transforms cells through dysregulation of several cell cycle checkpoints. Here, we review extant data on how Tax targets cyclins, inhibitors of cyclin dependent kinase, as well as cellular sentries for DNA-damage.

Keywords
Cell cycle regulation
Cellular transformation
HTLV-I
Adult T-Cell Leukemia
Tax Oncoprotein
MAD1
p53
Review
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