IMR Press / FBL / Volume 7 / Issue 4 / DOI: 10.2741/murray

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
The Role of the Epstein-Barr virus in human disease
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1 Department of Pathology, Division of Cancer Studies, Medical School, University of Birmingham, Birmingham, B15 2TT, UK
2 CRC Institute for Cancer Studies, Medical School, University of Birmingham, Birmingham, B15 2TT, UK
Academic Editor:Erle Robertson
Front. Biosci. (Landmark Ed) 2002, 7(4), 519–540; https://doi.org/10.2741/murray
Published: 1 February 2002
(This article belongs to the Special Issue DNA viruses and human malignancies)
Abstract

EBV is a B lymphotropic virus that is associated with a range of human malignancies. Although for many of these tumours the association has long been established, unraveling the precise role of EBV in disease pathogenesis has been more difficult. This review summarizes current knowledge concerning the association between EBV and human cancers and illustrates how an increasing appreciation of patterns of latent gene expression and latent gene function in different cell environments is already helping towards a better understanding of both the natural history of infection in normal individuals and how EBV contributes to malignant transformation. Finally, therapeutic strategies that target EBV in tumours are discussed.

Keywords
Epstein-Barr virus
Lymphoproliferative Disease
Immunosuppression
Burkitt’s lymphoma
Hodgkin's disease
T cell lymphoma
Nasopharyngeal Carcinoma
Review
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