Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
One of the major goals of transplantation biology is to overcome transplant rejection without the need for life-long immunosuppression. Over the last several years, fundamental advances in our understanding of the immune response to allogeneic and xenogeneic antigens have stimulated a great deal of interest in the possibility of using gene therapy approaches to overcome the host response leading to transplant rejection while alleviating the need for non-specific immunosuppression. Here, we review recent progress in the field on the use of gene therapy to induce transplantation tolerance to donor organs and tissues.