IMR Press / FBL / Volume 7 / Issue 4 / DOI: 10.2741/A793

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

The immunopathogenesis of Borna disease virus infection
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1 Institute for Immunology, Federal Research Center for Virus Diseases of Animals, Paul-Ehrlich-Strasse 28, D-72076 Tübingen, FRG
2 Institute for Neuropathology, Heinrich-Heine-Universität, Düsseldorf, FRG
Academic Editor:Patrick Lai
Front. Biosci. (Landmark Ed) 2002, 7(4), 541–555;
Published: 1 February 2002
(This article belongs to the Special Issue Persistent infection and immunity)

Borna disease virus (BDV) infection represents an excellent model system to study immunopathological mechanisms based on a T cell-mediated immune reaction in the central nervous system. The single-stranded RNA Borna disease virus, a member of Bornaviridae in the order of Mononegavirale, lacks cytopathogenicity both in vitro and in vivo. After experimental infection BDV causes a persistent infection of the central nervous system and induces Borna disease, an immune-mediated encephalomyelitis. The infiltrating immune cells have been characterized as CD4-positive, CD8-positive T-cells, macrophages and B cells. CD8-positive T cells represent the effector cell population exhibiting antigen specificity for the nucleoprotein.

Borna Disease
Persistent Infection
Central Nervous System
CD4+ T cells
CD8+ T cells
Cytotoxic T Lymphocytes
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