Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
Tuberculosis still remains a major threat to global health at the beginning of the 21st century. The extraordinarily high numbers of morbidity and mortality are due to the ability of the pathogen, Mycobacterium tuberculosis, to evade an effective immune response and to persist within the host organism for long periods of time. The following article reviews our knowledge about both pathogen and host mechanisms involved in the immune response to M. tuberculosis.