IMR Press / FBL / Volume 7 / Issue 4 / DOI: 10.2741/A783

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Mechanisms of DNA virus infection: entry and early events
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1 Department of Microbiology and Immunology, 6736 Medical Sciences II,University of Michigan School of Medicine, Ann Arbor, MI 48109-0620, USA
Academic Editor:Erle Robertson
Front. Biosci. (Landmark Ed) 2002, 7(4), 390–406; https://doi.org/10.2741/A783
Published: 1 February 2002
(This article belongs to the Special Issue DNA viruses and human malignancies)
Abstract

The cellular components engaged in entry of viruses has been an area of intense investigation in recent years. We examine the entry and receptors used for well-studied and prevalent human DNA viruses adenoviruses, poxviruses and two herpesviruses- herpes simplex virus and Epstein-Barr virus. Little is yet known about the entry or early events for other human DNA viruses. Common themes that emerge for entry of these prevalent human DNA viruses include engagement of multiple receptors, use of cell surface molecules that are prominent and, in most cases, conserved on cells, and interactions with proteins that can alter morphology of the cytoskeleton or modulate intracellular signaling for gene expression. Where available, we provide evidence that entry not only transports the capsid and genome across a cell membrane, but that these events also can set up the cell for subsequent events that contribute to successful viral replication.

Keywords
Viral Entry
Cell Receptors
Membrane Fusion
Viral Tropism
Viral Attachment
Viral Penetration
Uncoating
Viral Fusion Receptor
Review
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