IMR Press / FBL / Volume 6 / Issue 5 / DOI: 10.2741/A717

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

The role of bone marrow transplantation in first remission of paediatric all
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1 Institute of Child Health & Great Ormond Street Hospital & Children NHS Trust, University of London, 30 Guilford Street, London, WC1N 1EH, United Kingdom
Front. Biosci. (Landmark Ed) 2001, 6(5), 38–42;
Published: 1 August 2001

Although intensive chemotherapy has improved event-free survival for most children with lymphoblastic leukaemia there remain up to 10% who have not benefited from this approach. These include infants, children with Ph1 positive leukaemia, with near-haploidy, and slow remitters in most of whom event free survival remains below 40%. Evaluation of the benefits of Bone Marrow Transplantation in high risk ALL is fraught with difficulties and to date has not produced clear evidence of benefit. The way forward lies in prospective evaluation of BMT in tightly defined subsets of highest risk children, a task which will require international collaboration.

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