IMR Press / FBL / Volume 6 / Issue 4 / DOI: 10.2741/mcclain

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

The role of Epstein-Barr virus in systemic lupus erythematosus
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1 Oklahoma Medical Research Foundation, Oklahoma City, OK
2 University of Oklahoma Health Sciences Center, Oklahoma City, OK
3 U.S. Department of Veterans Affairs Medical Center, Oklahoma City, OK

Academic Editor: Robert Hoffman

Front. Biosci. (Landmark Ed) 2001, 6(4), 137–147;
Published: 1 October 2001
(This article belongs to the Special Issue Pathogenesis of systemic lupus erythematosus)

Systemic lupus erythematosus (SLE) is a devastating autoimmune disease with no known cure. Lupus patients suffer from a myriad of clinical symptoms which variably include arthritis, pleuritis, pericarditis, vasculitis, and nephritis. The underlying mechanisms behind these clinical findings and the etiologic events preceding and causing disease onset, however, remain largely unknown. For many years, investigators have suspected that Epstein-Barr virus might somehow be involved in the etiology and/or pathogenesis of systemic lupus. Numerous studies have examined this possibility from various angles and have arrived at different conclusions. This work reviews these historical papers in the context of new results and presents a hypothetical role for this virus as an etiological environmental trigger for SLE.

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