IMR Press / FBL / Volume 6 / Issue 4 / DOI: 10.2741/jones

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Recent cytoarchitechtonic changes in the prefrontal cortex of schizophrenics
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1 Department of Biological Sciences, Lehman College, CUNY, 250 Bedford Park Blvd. West, Bronx, NY 10468
Front. Biosci. (Landmark Ed) 2001, 6(4), 148–153;
Published: 1 November 2001

A variety of lines of converging evidence implicate the prefrontal cortex (PFC) in schizophrenia. In the past studies have focused on the various neurotransmitter systems that appear to be involved in schizophrenia such as dopamine, glutamate and serotonin. Recently, the focus of research has shifted away from systems and towards cellular morphology due partly to studies suggesting an increase in neural density in various regions of the PFC (1,2). A plethora of research has come out suggesting possible cytoarchitectural changes in pyramidal cells in the prefrontal cortex as well as alterations of certain GABAergic cells. This review examines the recent data that shows cytoarchitechtonic changes in cells of the prefrontal cortex.

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